What is Molecular Testing & why is it important?
Molecular testing for cancer is a way to look closely at your cancer cells to find alterations (mutations) and other special markers. Results from these tests can help physicians create a specialized plan for each person’s cancer by providing additional insight into your disease such as: how it might grow or what treatments you might respond to best. Molecular testing may also be referred to as genomic testing or profiling; biomarker testing; molecular profiling; or next generation sequencing.
How is molecular testing different from genetic testing?
Molecular (or genomic) testing looks at mutations specifically within your cancer cells. Genetic testing looks at inherited mutations that are in ALL cells and are passed on from your parents.
How is the test performed?
This testing is often done on a tissue sample of the tumor (from a previous biopsy or surgery). However, it might also be done using a sample of blood or saliva. The sample type required depends on the test being ordered by your physician.
Does NECS complete the testing?
No. NECS may draw a blood sample or obtain a saliva sample if required, the sample obtained is then sent to a special lab for the testing. If a tissue sample is required, the NECS team will help coordinate with the testing company to ensure they receive the proper sample.
What companies perform Molecular Testing?
The physicians at New England Cancer Specialists frequently order this testing from companies such as: Caris, FoundationOne, Guardant, NavDx, NeoGenomics, Signatera & Tempus. Our physicians constantly research new tests as they become available and will evaluate their appropriateness for our patient population.
Will my insurance cover this testing? What if I don’t have insurance?
Most often your insurance company will pay for the testing, but they might send you a statement called an Explanation of Benefits (EOB). An EOB is not a bill; it is a communication from your insurance company regarding the services you received from the testing company. It shows services that were billed to insurance and what insurance covered. An EOB may not require payment even if there is an amount due for patient responsibility. Patients may receive multiple EOBs if bundled testing options are selected by your provider.
If your insurance company issues a denial for testing, then the testing company will appeal on your behalf. They may reach out to you or your team at NECS, if they need additional information to submit their appeal(s).
If needed, there are Patient Assistance Programs to help pay for testing. Our Patient Advocates can help you apply for these programs. If you received an EOB or denial for testing and have additional questions, our Patient Advocate team is available to help.
